Hypersensitivity pneumonitis

Hypersensitivity pneumonitis (HP) is an inflammatory disease of the lungs and airways that develops in response to repeated inhalation a wide range aerosol antigens. The clinical picture course HP are highly variable depend on such factors as nature antigen, intensity duration exposure well characteristics patient's immune response. annual incidence HAP 1.28 -1.94 cases per 100 000. Currently, diagnosis usually based characteristic picture, high-resolution computed tomography (HRCT) data, bronchoscopy, lung biopsy, evidence antigen. HRCT plays central role HP. most common finding ground-glass opacities, which can be associated with centrilobular nodules air trapping. In some cases, fibrotic signs very similar those idiopathic pulmonary fibrosis (IPF), changes found lower regions subpleurally. Therapy for includes avoiding considering corticosteroids (CS) and/or immunosuppressive therapy suppress active inflammatory/immune response, treating comorbidities. Nintedanib patients progressive results slower decline function compared placebo.